Because IELT may be influenced by several factors and it is not expected to be normally distributed, it has been previously suggested that geometric mean may be preferred over average mean to correct for this skewed distribution. The increase from baseline in geometric mean values for IELT was also statistically significantly greater for dapoxetine 30 mg and 60 mg 'on demand' compared with placebo 'on demand' (p<0.001).
Benefits of Dapoxetine
Human ejaculation is primarily mediated by the sympathetic nervous system. The mechanism of action of dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre- and postsynaptic receptors (Priligy summary of product characteristics). It is licensed for the treatment of premature ejaculation in adult men aged 18 to 64 years. Dapoxetine should only be prescribed to men who meet all the following criteria: An intravaginal ejaculatory latency time of less than 2 minutes and An intravaginal ejaculatory latency time of less than 2 minutes and Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the man wishes and Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the man wishes and Marked personal distress or interpersonal difficulty as a consequence of premature ejaculation and Marked personal distress or interpersonal difficulty as a consequence of premature ejaculation and A history of premature ejaculation in the majority of intercourse attempts over the prior 6 months. A history of premature ejaculation in the majority of intercourse attempts over the prior 6 months.
Step 4 — Follow-Up and Ongoing Support
Dapoxetine should be administered only as on demand treatment before anticipated sexual activity. Dapoxetine should not be prescribed to delay ejaculation in men who have not been diagnosed with premature ejaculation. Dapoxetine must not be taken more frequently than once every 24 hours (Priligy summary of product characteristics). Dapoxetine is available at 2 different strengths: 30 mg and 60 mg. The recommended starting dose for all men is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity.
Further reading and references
Treatment should not be initiated with the 60 mg dose. If the individual response to 30 mg is insufficient and the man has not experienced moderate or severe adverse reactions or prodromal symptoms suggestive of syncope, the dose may be increased to a maximum recommended dose of 60 mg taken as needed approximately 1 to 3 hours prior to sexual activity. The incidence and severity of adverse events is higher with the 60 mg dose. The summary of product characteristics recommends that a careful appraisal of the individual benefit/risk ratio of dapoxetine should be performed by the clinician after the first 4 weeks of treatment (or at least after 6 doses of treatment) to determine whether continuing treatment is appropriate. Data regarding the efficacy and safety of dapoxetine beyond 24 weeks are limited. Whilst there is no generally agreed minimum clinically important change in IELT, Pryor et al.
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(2006) concluded that it was about 1 minute, based on a correlation of global impression of change scores with mean changes in IELT.
How to take dapoxetine tablets
There was a statistically significantly greater increase from baseline in mean IELT at 12 weeks with both dapoxetine 30 mg and 60 mg 'on demand' compared with placebo 'on demand' (from 0.9 minutes in all groups to 1.9, 3.1 and 3.6 minutes respectively for placebo, dapoxetine 30 mg and dapoxetine 60 mg; p<0.001 for comparisons with placebo). The RCTs that contributed to the pooled analysis also individually showed statistically significantly greater increases of similar magnitude in mean IELT at 12 weeks with both strengths of dapoxetine compared with placebo (p<0.001). One of the included studies (Buvat et al. 2009) was continued for 24 weeks and the statistically significant increase in mean IELT with dapoxetine 30 mg and 60 mg 'on demand' compared with placebo 'on demand' was still maintained at this time point (p<0.001). (2011) also presented exploratory analyses of geometric means (a measure of central tendency) for the 12-week IELT. In the pooled analysis, the improvement in mean 12-week IELT from baseline for the placebo group was 1 minute.
Pharmacologic Therapy
The clinical need of continuing and the benefit/risk balance of sildenafil dapoxetine tablets treatment should be re-evaluated at least every 6 months. Dapoxetine (Priligy) is available in packs of 3 and 6 tablets. For the 30 mg strength tablet, the costs are £14.71 for a pack of 3 tablets and £26.48 for a pack of 6 tablets. For the 60 mg strength tablet, the costs are £19.12 for a pack of 3 tablets and £34.42 for a pack of 6 tablets (MIMS, March 2014). This evidence summary is based on a pooled analysis of results from 5 phase III randomised controlled trials (RCTs) (McMahon et al.
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All 5 of the studies were conducted in heterosexual men aged 18 years and over who had been in a monogamous relationship for at least 6 months and who met the DSM-IV-TR criteria for premature ejaculation. In 4 of the studies, participants also had to have an intravaginal ejaculatory latency time (IELT) of 2 minutes or less in at least 75% of 4 or more sexual intercourse events at baseline. These 4 studies compared 'on demand' placebo, dapoxetine 30 mg and dapoxetine 60 mg over a 12‑ or 24-week period for the primary outcome of IELT, measured by a stopwatch held by the partner. The pooled analysis provides pooled data from these 4 studies for the mean average IELT at week 12. The 5th study compared dapoxetine 60 mg once daily, dapoxetine 60 mg 'on demand' and placebo over a 9-week period.
Derivative Synchronous Fluorescence Spectroscopy for the Simultaneous Determination of Dapoxetine Hydrochloride and Vardenafil in Binary Mixtures
Design: pooled analysis of 5 phase III RCTs: 2 identically designed 12-week randomised, double-blind, placebo-controlled, parallel group studies from the USA (Pryor et al. 2006); a 24-week randomised, double-blind, parallel group, placebo-controlled study primarily conducted in Europe and South America (Buvat et al. 2009); a 12-week randomised, double-blind, placebo-controlled, parallel group study in Asia-Pacific countries (McMahon et al. 2010); and a 9-week randomised, double-blind, placebo-controlled, parallel group study from North America (Kaufman et al. Population: the pooled analysis included 6081 men aged 18 years and over (mean age 41; 71% white) who had been in a monogamous heterosexual relationship for at least 6 months and who met DSM-IV-TR criteria for premature ejaculation. In the pooled analysis, the difference between placebo and dapoxetine 30 mg for the improvement in mean 12-week IELT was 1.2 minutes.
- Dapoxetine is sometimes used off-label to treat other sexual dysfunctions.
- It is not a cure but a symptom management medication.
- Men should discuss potential side effects thoroughly before starting treatment.
- The medication has been studied and approved in several countries for PE.
- In case of overdose, seek emergency medical help immediately.
- Dapoxetine use requires careful monitoring for long-term safety.
In both the pooled analysis and the individual studies, the difference between dapoxetine 30 mg and 60 mg 'on demand' for the mean IELT at 12 weeks was less than 1 minute (0.5 minutes for the pooled analysis; no statistical analysis reported).
- Combining dapoxetine with recreational drugs can be dangerous and is not recommended.
- Dapoxetine can improve quality of life in men with PE.
- Always consult a healthcare provider before starting or stopping medication.
- Maintain open communication with your partner about treatment options.
- Lifestyle adjustments, like reducing stress, can complement medication treatment.
- Regular health screenings are advised during dapoxetine therapy.
The percentage of men who reported that their premature ejaculation was 'better' or 'much better', and who reported 'good' or 'very good' satisfaction with sexual intercourse and 'good' or 'very good' perceived control over ejaculation was statistically significantly higher with dapoxetine 30 mg and 60 mg 'on demand' compared with placebo 'on demand' (all p<0.001, see table 1 for details).
| Side Effect | Frequency | Severity | Management Tips |
|---|---|---|---|
| Nausea | Common | Mild to moderate | Take with food, follow dose instructions |
| Dizziness | Common | Mild | Avoid driving after taking |
| Insomnia | Occasional | Mild | Use earlier in the day if sleep disturbances occur |
| Sudden Drop in Blood Pressure | Rare | Moderate | Monitor BP if prone to hypertension |
| Serotonin Syndrome | Very Rare | Severe | Discontinue and seek medical attention if symptoms occur |
However, the differences between the 30 mg and 60 mg strengths were small (no statistical analysis reported).
| Attribute | Description | Notes |
|---|---|---|
| Purpose | Delays ejaculation time during intercourse | Often prescribed for PE |
| Typical Dosage | 30 mg to 60 mg | Taken 1-3 hours before sex |
| Onset of Action | Within 1-3 hours | Peak effect approximately 1 hour after intake |
| Duration of Effect | 2 to 4 hours | Varies per individual |
| Common Side Effects | Nausea, dizziness, headache | Usually mild |
| Contraindications | Use with MAO inhibitors, severe cardiac issues | Consult doctor before use |
In addition, the majority of men in the dapoxetine groups (69.3% in the 30 mg group and 61.7% in the 60 mg group) did not report that their PE was 'better' or 'much better'.
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In 4 of the studies, participants also had to have an IELT of 2 minutes or less in at least 75% of 4 or more sexual intercourse events at baseline. Participants in the studies reported having premature ejaculation for an average of 15 years, with 65% of participants considered to have lifelong premature ejaculation by the study investigators. In those participants in whom it was recorded (n=4832), average IELT at baseline was 0.9 minutes. Intervention and comparison: in 4 studies (Pryor et al. 2006 [2 studies reported], Buvat et al.
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2010) (n=4843), participants were randomised 1:1:1 to placebo, dapoxetine 30 mg or dapoxetine 60 mg to be taken 'on demand' (1 to 3 hours before anticipated sexual intercourse). (2009) (n=1238), participants were randomised 2:2:1 to dapoxetine 60 mg once daily, dapoxetine 60 mg 'as needed' and placebo. 2010) evaluated IELT as the primary outcome, defined as the duration of time from penetration to intravaginal ejaculation and measured by a stopwatch held by the female partner during each episode of intercourse. Secondary outcome measures in these 4 studies included patient-reported outcomes such as the clinical global impression of change in premature ejaculation (where participants were asked to rate their premature ejaculation as 'much worse', 'worse', 'slightly worse', 'no change', 'slightly better', 'better' or 'much better') and items from the Premature Ejaculation Profile (PEP), a validated tool that includes measures of perceived control over ejaculation. Missing post-baseline data were substituted with the last post-baseline observation carried forward.
Quality assessment
Three of the included studies (Pryor et al. 2009) stated that participants were expected to attempt sexual intercourse 6 or more times each month during the study period. Safety outcomes included pooled data from all 5 studies for adverse events and safety observations of well-recognised selective serotonin reuptake inhibitor (SSRI)-related effects concerning mood, akathisia, anxiety, suicidality or SSRI discontinuation syndrome reported separately from each study. Table dapoxetine order online 1 Summary of pooled analysis McMahon et al. The pooled analysis of results from 4 phase III studies showed that there was an increase from baseline in mean IELT at 12 weeks with all 3 groups, including the placebo group. (2011) also presented pooled analyses from 2 of the included studies (Buvat et al.
| Aspect | Details |
|---|---|
| Drug Class | Selective Serotonin Reuptake Inhibitor (SSRI) |
| Mechanism of Action | Increases serotonin levels in the nervous system, delaying ejaculation |
| Half-Life | Approximately 19 hours |
| Metabolism | Liver (via CYP enzymes) |
| Excretion | Primarily in urine |
| Interaction Potential | May interact with other serotonergic drugs |
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