Development of a sexual function questionnaire for clinical trials of female sexual dysfunction.
Efficacy of Sildenafil Citrate on Female Sexual Dysfunction in A Sample of Egyptian Females, A Prospective Placebo Controlled Study
If you are taking sildenafil for PAH, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Tell your doctor if any of these symptoms are severe or do not go away: numbness, burning, or tingling in the arms, hands, feet, or legs pain in muscles, back, arms, or legs changes in color vision (seeing a blue tinge on objects or having difficulty telling the difference between blue and green) If you experience any of the following symptoms, call your doctor immediately: sudden severe loss of vision (see below for more information) erection that is painful or lasts longer than 4 hours rash; itching; hives; difficulty breathing or swallowing; swelling of the eyes, face, throat, tongue, or lips Some patients experienced a sudden loss of some or all of their vision after they took sildenafil or other medications that are similar to sildenafil. The vision loss was permanent in some cases.
Key takeaways
It is not known if the vision loss was caused by the medication. If you experience a sudden loss of vision while you are taking sildenafil, call your doctor immediately. Do not take any more doses of sildenafil or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor. There have been reports of heart attack, stroke, irregular heartbeat, bleeding in the brain or lungs, high blood pressure, and sudden death in men who took sildenafil for erectile dysfunction. Most, but not all, of these people had heart problems before taking sildenafil.
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It is not known whether these events were caused by sildenafil, sexual activity, heart disease, or a combination of these and other causes.Talk to your doctor about the risks of taking sildenafil. Some patients experienced a sudden decrease or loss of hearing after they took sildenafil or other medications that are similar to sildenafil. It is not known if the hearing loss was caused by the medication. If you experience a sudden loss of hearing, sometimes with ringing in the ears or dizziness, while you are taking sildenafil, call your doctor immediately. If you are taking sildenafil (Viagra) for erectile dysfunction, do not take any more doses of sildenafil (Viagra) or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor. J Womens Health Gend Based Med 2002; 11: 277–289.
| Use | Description | Typical Dosage | Notes |
|---|---|---|---|
| Female Sexual Arousal Disorder | Helps increase blood flow to enhance arousal | 25-50 mg | Prescribed by a doctor |
| Pulmonary Hypertension | Off-label use for specific pulmonary issues | 20 mg | Under medical supervision |
| Enhancing Clitoral Blood Flow | Used to improve clitoral responsiveness | Variable | Not FDA-approved for women |
| Treatment of Female Dyspareunia | Aims to reduce pain during intercourse | Experimental | Limited clinical trials |
The use of the sexual function questionnaire as a screening tool for women with sexual dysfunction.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Viagra Generic | 150mg | 120 + 8 Pills | 177.58€ 169.12€ | |
| Kamagra Soft Tabs | 100mg | 20 Pills | 79.79€ 75.99€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ | |
| Viagra Generic | 100mg | 270 + 10 Pills | 270.47€ 257.59€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ | |
| Viagra Generic | 150mg | 90 + 6 Pills | 147.18€ 140.17€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Kamagra | 100mg | 32 Pills | 121.24€ 115.47€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Viagra Generic | 100mg | 90 + 6 Pills | 129.02€ 122.88€ |
Development of a questionnaire on sexual quality of life in women.
| Country | Legal Status | Prescription Required | Notes |
|---|---|---|---|
| USA | Approved for certain uses | Yes | Off-label for women often not approved |
| UK | Prescription-only | Yes | Approved for male ED; off-label use in women |
| Canada | Restricted use | Yes | Prescription required; variable by province |
| Australia | Prescription-only | Yes | Limited clinical guidelines for women |
Phosphodiesterase type 5 inhibitors and female sexual response: faulty protocols or paradigms?
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Sexual activities, desire, and satisfaction in males pre- and post-spinal cord injury. Arch Sex Behav 1993; 22: 217–228. Sexual arousal and orgasm in women: effects of spinal cord injury. The effects of spinal cord injury on psychogenic sexual arousal in males. Sexual responsiveness in women with spinal cord injuries: differential effects of anxiety-eliciting stimulation. This study was sponsored by Pfizer Inc.
What special dietary instructions should I follow?
The information is not a substitute for medical care. To evaluate the efficacy, safety and tolerability of oral sildenafil in women with female sexual arousal disorder as a result of SCI (paraplegia/tetraplegia). The study was conducted at clinical practice sites in North America (n =23), 11 European countries (n =23), Australia (n =4) and South Africa (n =2). 129 women were randomized and treated with sildenafil or matching placebo. A 4-week baseline period was followed by 12 weeks of treatment, which could be increased from 50 to 100 mg or decreased to 25 mg once during the treatment period, depending on efficacy and tolerability.
How should sildenafil for women be used?
By use of an event log, sexual activity was monitored between screening and the end of treatment. The Sexual Function Questionnaire, the Sexual Quality of Life Questionnaire–Female, a global efficacy question and Sexual Distress Question were also assessed. Sildenafil-treated women and placebo-treated women had an increase in their percentage of sexual activities throughout the course of the study, with no statistically significant difference between groups in the percentage of successful sexual activities at end of treatment versus baseline. There were also no statistically significant differences between sildenafil- and placebo-treated women on the aforementioned measures. The most sildenafil 100 mg cost common adverse events included headache and vasodilatation.
Related medical questions
The results of this study are similar to other reports regarding a lack of clinically meaningful benefit of sildenafil in other populations of women. This study was sponsored by Pfizer Inc. Gain free access to this article, as well as selected content from this journal and more on nature.com Targeting recovery: priorities of the spinal cord-injured population. Targeting recovery: priorities of the spinal cord-injured population. Sexual activities, response and satisfaction in women pre- and post-spinal cord injury. Editorial support was provided by Anne Johnson, Janet E Matsuura, PhD, and Deborah M Campoli-Richards, BSPharm, RPh, of Complete Healthcare Communications, Inc., and was funded by Pfizer Inc.
Non-medical use
A two-part pilot study of sildenafil (VIAGRA) in men with erectile dysfunction caused by spinal cord injury. Hultling C, Giuliano F, Quirk F, Peña B, Mishra A, Smith MD . Quality of life in patients with spinal cord injury receiving Viagra (sildenafil citrate) for the treatment of erectile dysfunction. Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR 4th edn (Text Revision). Marca Sipski Alexander reports no commercial interests with the study sponsor.
- Doctors may prescribe sildenafil off-label for women based on individual assessment.
- Patient education about realistic expectations is essential when using sildenafil.
- Sildenafil’s mechanism involves enhancing nitric oxide signaling in blood vessels.
- Women with liver or kidney problems need careful evaluation before sildenafil use.
- Viagra was initially tested for women before focusing on men’s erectile issues.
- Alternative options like vaginal lubricants are also common for female sexual problems.
Raymond Rosen reports no current commercial interests with the study sponsor.
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Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
Effects on sexual dysfunction
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use. The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc.
What should I know about storage and disposal of sildenafil?
makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. At the time of this research, Dr Rosen served as a consultant and research advisor for Pfizer Inc.
- Sildenafil is a medication primarily used to treat erectile dysfunction in men.
- Women sildenafil is an off-label use aimed at improving female sexual arousal.
- Clinical trials are ongoing to assess efficacy of sildenafil for women.
- Side effects of sildenafil may include headaches, flushing, and nasal congestion.
- Women may experience increased blood flow and libido with sildenafil.
- Proper dosage and medical consultation are essential before use.
Claes Hultling reports no commercial interests with the study sponsor.
Does Viagra work for women?
Arch Sex Behav 2004; 33: 295–302. Effects of level and degree of spinal cord injury on male orgasm. Giuliano F, Hultling C, El Masry WS, Smith MD, Osterloh IH, Orr M et al. Randomized trial of sildenafil for the treatment of erectile dysfunction in spinal cord injury. Maytom MC, Derry FA, Dinsmore WW, Glass CA, Smith MD, Orr M et al. Tara Symonds and Scott Haughie are employees of Pfizer.
- Clinical research into sildenafil for women includes various dosage trials.
- Women using sildenafil should monitor blood pressure to avoid adverse effects.
- The safety profile of sildenafil in women is less documented than in men.
- Sildenafil’s impact on female sexual desire is still under scientific investigation.
- Women should avoid sildenafil if pregnant or breastfeeding unless prescribed.
- Alternative therapies for female sexual dysfunction include counseling and hormone therapy.
Susanne Steinberg was an employee of Pfizer when the study was conducted.
| Age Group | Considerations | Recommended Dosage | Notes |
|---|---|---|---|
| 20-30 years | Generally healthy | 25 mg | Consult doctor if contraindicated |
| 31-50 years | Possible hormonal changes | 25-50 mg | Monitor for side effects |
| 51+ years | Increased health risks | 25 mg | Under medical advice |
| Postmenopausal | Effectiveness varies | Variable | Focus on overall health |
Sildenafil in women with sexual arousal disorder following spinal cord injury. Sexual Health in the Neurogenic Patient Current Bladder Dysfunction Reports (2020) Knowledge Gaps in Urologic Care of Female Spinal Cord Injury Patients Current Urology Reports (2019) Sexual Function after Spinal Cord Injury: Innervation, Assessment, and Treatment Current Sexual Health Reports (2016)
What happens if a woman takes Viagra?
If you are taking sildenafil (Liqrev, Revatio) for PAH, do not stop taking your medication until you talk to your doctor. Call your doctor if you have any unusual problems while you are taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088). Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom).
Exploratory Phase 2b RESPOND Study, Completed in 2023
Store the suspension at room temperature or in a refrigerator, but do not freeze it. Dispose of any unused suspension after 60 days. Keep all medication out of sight and reach of children as many containers are not child-resistant. Place the medication in sildenafil gel a safe location – one that is up and away and out of their sight and reach. Dispose of unneeded medications in a way so that pets, children, and other people cannot take them.
Altitude sickness
Do not flush this medication down the toilet. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website for more information. In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.